Not drinking any water but drooling and swallowing all the time. My 2 year old Shepherd was perfectly healthy in Feb. and by April of this year he quit eating, excessive thirst, excessive urination, low platelet count, low red blood cell count is unsteady and now is at a vet hospital and so far we have spent 2000 and they do not know what is wrong with him. I will update once we have results from diagnostics. As of today, Sadie's ability to eventually meet the strict certification requirements in that pursuit, remains guarded, although her progress prior to this event had been stellar. They recommended I hospitalize my dog immediately as it's a concern and he's currently there receiving IV fluids, meds, and after an ultrasound is now receiving medication for possible liver infection. That sh-t should be banned. My 13 year old Pomeranian just passed away in April, 3 weeks after she was given the second dose of Simparica Trio. She hasnt eaten in 3 days and is unable to go up 2 simple steps. Its Sunday night and still vomiting. Training your dog to follow basic commands builds a positive relationship with her and helps ensure her safety. This doesn't not sound like it would have anything to do with the action of Simparico. Gastrointestinal issues: Some dogs may experience vomiting, diarrhea, or decreased appetite after taking Simparica Trio. Hi Laura, just wondering what supplements you gave your pup to help and how long it took for her to get back to herself after simparica. This is because drugs in the isoxazoline class have been associated with neurologic reactions including seizures, tremors, and ataxia in dogs with or without a history of neurologic disorders. Any response from the company? Haven't noticed any other symptoms to him besides the puking, not eating and skittish. He is back to his old self now but we will never give him this medication again. They have increased and worsened over the last 3 months. All we want to do is take the best care of our animals and trust the people (Vet's) who specialize in this to do what's right for them. I notified my vet and Zoetis, the company that makes this drug. He had a serious skin issue a few months back and it was blamed on fleas. She was riddled with parasites when she was found as a stray, and then treated for heartworm disease just before I adopted her. Simparica Trio (sarolaner, moxidectin, and pyrantel chewable tablets), is the first once-monthly, chewable tablet that delivers all-in-one protection from heartworm disease, ticks and fleas, roundworms and hookworms. The following day he died. With Entyce she is getting her appetite back and seems a little better. Doctor prescribed the salyien with some injunction but all are in vain..my labrador has same issues till datemy vet.not says anything about the side effect of the Simparica..i m now helpless..pls help me what should I do.. please help me to rid over itpls pls ..guide me. My sincere sympathies to those with horrendous seizure side effects. She had a beautiful coat of fur. The veterinary medicinal product should be administered at a dose of 1.2-2.4 mg/kg of sarolaner, 0.024-0.048 mg/kg of moxidectin and 5-10 mg/kg of pyrantel in accordance with the following table: Bodyweight (kg) Tablet strength 3 mg/0.06 mg/12.5 mg. Tablet strength 6 mg/0.12 mg/25 mg. I just hope he has a turn around . I never saw a flea because he has a very thick coat. Kristine, unfortunately my sweet Dolly passed away on October 9th. I hope this drug has not caused permanent damage. I am very worried I called the vet they said oops sorry they made a mistake. This all-in-one tablet can help make it easier to keep pesky parasites away this spring (and all year long). Especially after seeing these post. He started having skin issues that the vet said were allergic reactions probably due to environmental things. The active ingredient of Simparica, sarolaner, belongs to a newer class of flea and tick preventatives called isoxazolines. Plan to take him to see the vet tomorrow. Side effects are uncommon, but may occur in some cases. What kind of supplements are you giving her? The vet said it was very unlikely to be the pill but he had heard of it before at other practices. Did you ever do an MRI or spinal tap? How did your baby do please? (toy aussie & corgi). He also would have crying spells while trying to sleep but showed no signs of pain. Lost his appetite & was low on energy all day yesterday, slept most of the day - which is very unusual for him. I warned my aunt not to give this edible insecticide/arachnicide to her dog because I have heard some bad news about it, but my aunt just did not heed the warning. Our guy is having pain and is showing arthritic symptoms. This sounds so scary. She has been taking Trifexis for years with no problem. Im wondering if anyone else has seen these types of symptoms. Simparica has caused my 12 pound 5 year old Jack Russel Terrior mix to have leg tremors and have trouble walking, jumping, or running. She text me asking if she ever had seizures before. Fortunately, no seizures but dark yellow diarrhea and puppy has been drinking water like crazy and peeing even while asleep. She won't drink E walk or anything The doctor seemed to push this drug on me because the kombi guard was on back order. A couple of weeks later she had lost weight from not eating. . Monday morning - 11 days after he is like a zombie - all motions are almost mechanical and when I talk to him it takes him a long while to react. My vets comment was I would know if his symptoms were related if at time for next dose his symptoms were gone they are gone. How common are Simparica side effects? He shakes and pants because of all the noises (turn signals, cars, radio, ect. We ended up encouraging him to eat something by spoon feeding him. This medicine needs to be stopped. When did you stop giving the Simparico Trio? No side effects. Does this sound familiar to anyone? Took to vet and she said it could be the Simparico Trio. I have reached out to the company but one email bounced and the other was an online form. He just couldn't stand good, he constantly shakes his head. We took him to vet and they gave nausea meds and kept him overnight. Vet said they dont think it has anything to do with the Simparica. We gave Simparica two days ago and he's not had an appetite, he's eating grass, is drinking a lot of water and sleeping. Vets at Petsmart should know better; changing vets. The reaction lasted less than 12 hours. Hi how is your pup now? I shall be looking for a natural product from now on, k and g pet supplies on amazon do a good mange spray so hopefully that will be all they need from now on. Tell your veterinarian if your dog has a history of seizures or other neurologic disease. If anyone has discovered what can help please let me know. My American Akita puppy took this pill on August 8th. I will not be continuing with this treatment. He seems sometimes anxious and is sensitive to noise outside. Your veterinarian may recommend a heartworm test if you are using Simparica Trio. Coincidence? Never again are my dogs getting oral medication for fleas & ticks. Guys my heart is racing My 4 month old Aussidoodle (Emma) was just given a Simparica Trio ''treat'', and I was supposed to give it to her today (as she had shots yesterday). I would absolutely rather be safe than sorry.. no more simparica trio for that guy. The company is reimbursing for vet costs. Both of them aren't eating like they were. Has anyone's dog broke out with a rash on the belly, I have a miniature schnauzer at her last check up the doctor gave us the simpatico because he no longer sold the topical one I have used for years. And a bit more stumbling. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). Why would he knowingly recommend this? I went to zoetis and Expressed my views and they said the FDA report meant nothing and it was in America. He doesn't seem to be throwing up as much anymore, he did several times throughout the night though. Although the mother that took the same had not shown any effects. Simparica Trio can be administered to your dog at any age, but it's best to start treating your dog . He had to be put to sleep and Im devastated. A day and a half after her 3rd dose of Simparica she had a really bad gran mal seizure and we though she was going to die. We think that the drug is the cause of the seizures . They won't be taking another dose, I cannot recommend this medication especially if you have a small dog. Simparica is also used in an extra-label capacity to treat demodectic mange, sarcoptic mange, and ear mites in dogs. One has done great only notice that he is drinking a lot of water. The diarrhea and vomiting went away after a few days but the cough has lingered for over a month now even with treatment. Then things got progressively worse. Was prescribed Simparica Trio for my Catahula dog with no medical issues. I never missed a day. after a few months of this i decided to go back to Sentinel and Bravecto. I am not giving him his dose this month and seeing what happens. Hoping that these side effects dont get worse and subside soon . So I started searching and came across this blog and my heart just sank. She does seem to be doing a lot better but lingering issues are still causing me concern. I have to turn him around and lead him away. Gastrointestinal Issues: Some dogs may experience diarrhea, vomiting, or a decreased appetite after taking Simparica Trio. However a spinal tap of the fluid surrounding the spinal cord would be need to prove your dog indeed has spinal meningitis and then to treat for the specific bacterium or viral causes. Simparica Trio should be used with caution in dogs with a history of seizures. I hope the best for you and dog, I know its a tough time. Then gave me pills of prednisone for him to take 1 pill twice a day . My shepherd got it the following month and I called the vet again and she prescribed probiaotics and anti diarrhea meds again. Vet office said make sure to give with food. No more of this med! I will use Sentinel and Pet Armor on her as this is what I have always gjven my dogs with no problems. After about 2.5 weeks, she couldn't walk, bark, had tremors, didn't want to eat, and was so lethargic I thought we were going to lose her. This content shouldnt take the place of advice by your vet. I called our Vet on the second day and they said they doubted very seriously that the Simparica would have give him diarrhea, and then told me that I should wait and see what happens with the next dose, because I had also told them that he had some drippings from some ground beef over his dog food the day before I gave him that first dose. My French bulldog 2 years olds had a second attack in 3 days. I'm besides myself. I gave it to him later in the month which was followed by a neurological event (ataxia, wetting himself, disorientation, and tremors). 8 months of prednisone and around the clock nursing care at home saved her life. Company asked us to do diagnostic testing at vet. how long do simparica trio side effects last Author: Published on: in what way did this ruling produce a fundamental change in the united states 21 septiembre, 2020 Published in: hicks family genealogy This medicine is making her shaky/tremor, anxious, and she is panting a ton. We rushed him to the emergency vet and they put him on keppra to stop the seizures. I called my vet but because of Covid they are so behind in appts and would not see him until a month from then. this link is to an external site that may or may not meet accessibility guidelines. He is eating fine with no diarrhea or vomiting. Never any issues with bravecto so we'll return to that medication. and lack of appetite. 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